Fig. 6: NDP52^GE is a protective factor in AD and counteracts pTAU accumulation.

Illustration of the highlights of the work. By using two in vitro systems, we showed that the NDP52^GE variant counteracts the accumulation of pathological pTAU better than NDP52^WT, through the autophagy process. Furthermore, we showed in vivo, in a Drosophila melanogaster model of TAU-mediated AD that the NDP52^GE variant partially rescues different pathological phenotypes induced by hTAU expression. Finally, using a genetic association case-control analysis, we showed that NDP52^GE is a protective factor in AD. Created with BioRender.com.