Fig. 5: MTCH2 regulates the expression of RRM1 and NRF2. | Cell Death & Disease

Fig. 5: MTCH2 regulates the expression of RRM1 and NRF2.

From: MTCH2 regulates NRF2-mediated RRM1 expression to promote melanoma proliferation and dacarbazine insensitivity

Fig. 5

A, B Immunofluorescence analysis was used to analyze the expression of NRF2 and RRM1 in MTCH2 knockdown or MTCH2 overexpressing A375, SK-MEL-21 and the control cells. Scale bars = 20 μm. C, D The protein level of RRM1 and NRF2 were analyzed in the stably MTCH2 knockdown or MTCH2 overexpressing A375, SK-MEL-21 and that the control cells. E, F NRF2 expression in nucleus and cytoplasm of MTCH2 knockdown or MTCH2 overexpressing A375 and SK-MEL-21 cells. The data represent three independent experiments. Each bar represents mean ± SD. p values were calculated using a Student’s t test (*p < 0.05, **p < 0.01, ***p < 0.001 vs. each control).

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