Fig. 6: SLC25A42 promotes GC cell proliferation and inhibit ferroptosis by activation of FAO. | Cell Death & Disease

Fig. 6: SLC25A42 promotes GC cell proliferation and inhibit ferroptosis by activation of FAO.

From: SLC25A42 promotes gastric cancer growth by conferring ferroptosis resistance through enhancing CPT2-mediated fatty acid oxidation

Fig. 6

A BODIPY (493/503) staining assay was used to assess lipid amount in SLC25A42-silencing MKN-1 and SLC25A42-overexpresing SNU-638 cells. Scale bar, 20 μm. The amounts of triglycerides (B), phospholipids (C), cholesterol (D), and free fatty acids (E) were determined in GC cells. The levels of NADPH (F) and ROS (G) were determined in GC cells. FI. fluorescence intensity. Scale bar, 20 μm. The CCK8 (H) and colony formation (I) assays for comparing the proliferative potential in SLC25A42-overexpresing SNU-638 cells treated with etomoxir. J Flow cytometry was utilized to investigate the rates of cell death in SLC25A42-overexpresing SNU-638 cells treated with etomoxir. *P < 0.05.

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