Fig. 7: NTS signaling in human MASLD. | Cell Death & Disease

Fig. 7: NTS signaling in human MASLD.

From: Neurotensin promotes hepatic steatosis by regulating lipid uptake and mitochondrial adaptation in hepatocytes

Fig. 7

A Gene expression data of PGC1α in liver biopsy samples from MASLD patients at different stages of the disease (Tukey’s HSD test) in EMBL-EBI database. B OXPHOS complex expression in normal, MASLD and MASH human liver samples (western blot). Data were normalized to TOM20 expression. C Correlation analyses of NTSR1 and OXPHOS complex I expression in liver samples from human patients. r = Spearman rho; 95% confidence interval lines are shown in red. D Correlation analyses of NTSR1 and CD36 expression in human liver samples. r = Spearman rho, 95% confidence interval lines are shown in red. E Regulation of CD36 and PGC1α expression (qPCR) by NTS in THLE2- human hepatocyte cells, normalized to β-actin N = 4. F NTS impairs mitochondrial function of THLE-2 cells (mito stress test). N = 10 datapoints from 2 independent experiments. G Schematic diagram showing liver lipid metabolism in absence (left) and presence (right) of NTS signaling and its consequence on MASLD initiation. Data are expressed as mean ± SD, and p ≤ 0.05 is considered significant.

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