Fig. 7: Schematic diagram of senescent cell induction of Macrophage-Myofibroblast Transition (MMT), which may result in tissue fibrosis. | Cell Death & Disease

Fig. 7: Schematic diagram of senescent cell induction of Macrophage-Myofibroblast Transition (MMT), which may result in tissue fibrosis.

From: Cellular senescence promotes macrophage-to-myofibroblast transition in chronic ischemic renal disease

Fig. 7

We identified a critical role for macrophages in giving rise to myofibroblasts, contributing to interstitial fibrosis in RAS through mesenchymal transition (MMT). This process appears to be mediated, at least in part, by senescent cell-derived IFITM3, which promotes ITGB3 expression and activates the TGF-β/Smad3 signaling pathway.

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