Fig. 1: Identification of cancer stem cells and key molecules for maintaining stemness in oral cancer.
From: KLF7-regulated ITGA2 as a therapeutic target for inhibiting oral cancer stem cells
A UMAP illustrating cell type diversity in human OSCC (55k cells). B UMAP plot of the subtype of malignant cells analyzed by scRNA-seq. C Heatmap depicting enriched pathway of the subtype of malignant cells. D CytoTRACE plot of the subtype of malignant cells. E Stem-like gene sets activity (AUCell score) in all malignant cells (umap plots, left panel) or per transcriptional state (violin plots, right panel). F The log2-transformed fold change (FC) in RNA levels between the stem-like cluster with the rest of the clusters and the high enrichment in the stem-related pathway. G KLF7 expression in OSCC and normal samples. H Representative immunohistochemistry image showing the expression of KLF7 in human OSCC tissue. Scale bar, 100 μm. I Kaplan–Meier curve of KLF7 in OSCC TCGA dataset. J Representative immunofluorescent image showing the expression of KLF7, CD44, CD133, and DAPI in human OSCC tissue. Scale bar, 100 μm (top); Scale bar, 20 μm (bottom).
