Fig. 2: Stiff substrate induced malignant cellular phenotypes and elevated ROCK1 expression. | Cell Death & Disease

Fig. 2: Stiff substrate induced malignant cellular phenotypes and elevated ROCK1 expression.

From: Extracellular matrix stiffness in endometrial cancer: driving progression and modulating treatment sensitivity via the ROCK1/YAP1 axis

Fig. 2

A The schematic of cell culture on a polyacrylamide Gel. B Cell morphology and cytoskeleton staining of endometrial cancer cells on soft and stiff substrates. Scale: 50 μm. C Cell apoptosis ratio and statistical analysis of cells cultured on different stiff substrates. D The expression of ROCK1, PARP, cleaved-PARP, cyclinB1, cyclinD1, and CDK4 in Ishikawa and HEC-1A cells cultured with different stiffness substrates. ***P < 0.001. Error bar refers to the mean and SD.

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