Fig. 7: Elevated ROCK1 expression induced progesterone resistance in EC cells. | Cell Death & Disease

Fig. 7: Elevated ROCK1 expression induced progesterone resistance in EC cells.

From: Extracellular matrix stiffness in endometrial cancer: driving progression and modulating treatment sensitivity via the ROCK1/YAP1 axis

Fig. 7

A Cell apoptosis in ROCK1-overexpressing and control cells after treatment with MPA, Y-27632, or their combination. B Cell apoptosis in Ish-MR cells after treatment with MPA, Y-27632, or their combination. C Colony formation assay of cells treated with MPA, Y-27632, or their combination. D Immunofluorescence staining of the cell cytoskeleton in cells treated with MPA, Y-27632, or their combination. (Note: The immunofluorescence image for the Y-27632 0 μM in this panel is also presented in Fig. 2B(Ishi-MR Stiff group), as both represent the same experimental group under identical treatment.). E In vivo xenograft experiments to evaluate the effects of MPA, Y-27632, and their combination on tumor growth. F IHC staining of Ki-67 in mouse tumors. G Body weight measurements of mice prior to sacrifice. Scale: 50 μm. *P < 0.05, **P < 0.01, ***P < 0.001, Error bar refers to mean and SD.

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