Fig. 6: Digoxin decreases the number of CCCs in the MKN45 orthotopic xenograft model. | Cell Death & Disease

Fig. 6: Digoxin decreases the number of CCCs in the MKN45 orthotopic xenograft model.

From: Digoxin promotes anoikis of circulating cancer cells by targeting Na+/K+-ATPase α3-isoform

Fig. 6

A A schematic overview of the experimental procedure for isolation of CCCs from mice. Immunocytochemistry was performed using antibodies for α3NaK (green), EpCAM (red; B), and flotillin-2 (red; C) in CCCs. Scale bars, 10 μm. D The number of CCCs was compared between control (n = 9) and digoxin-treated (n = 10) mice. **p < 0.01.

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