Fig. 6: KLF13 directly binds to GPIHBP1 and regulates its transcription. | Cell Death & Disease

Fig. 6: KLF13 directly binds to GPIHBP1 and regulates its transcription.

From: KLF13 promotes esophageal cancer progression and regulates triacylglyceride and free fatty acid metabolism through GPIHBP1

Fig. 6

A Pie chart showing Chip-seq promoter results, illustrating the KLF13 binding region. B Venn diagram of genes overlapped between the RNA-seq and Chip-seq promoter results. C The motif sequence of KLF13. D ChIP-seq peak in the GPIHBP1 promoter region of the human genome. E Predicted KLF13 binding site in the GPIHBP1 promoter region. F–I GPIHBP1 expression after KLF13 knockdown or KLF13 overexpression in EC cells. J KYSE-450 cells were co-transfected with KLF13 overexpressing plasmids, as well as control and luciferase reporter plasmids containing the GPIHBP1 promoter. K KLF13 ChIP experiments (IgG as an internal control). L Association between KLF13 and GPIHBP1 expression using TCGA samples. M GPIHBP1 immunohistochemistry results in EC and normal tissue samples. Bar = 100 μm. N Immunohistochemistry results for GPIHBP1 in KLF13 high- or low-EC tissue samples. Bar = 100μm.

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