Fig. 5: GPX2 augments the Sonic Hedgehog pathway via accelerating ROS scavenging. | Cell Death & Disease

Fig. 5: GPX2 augments the Sonic Hedgehog pathway via accelerating ROS scavenging.

From: N6-methyladenosine-modified GPX2 impacts cancer cell stemness and TKI resistance through regulating of redox metabolism

Fig. 5

A ROS production in gefitinib-treated A549 and HCC827-GR cells transfected with scramble or GPX2 shRNA in the presence or absence of ROS scavenger (NAC). B Quantitative analysis of ROS production. C GLI1, CD133 and ALDH1A1 expression in GPX2-knockdown A549 and HCC827GR cell lines treated with NAC. D Cell viability was detected for evaluating the effect of supplementation with NAC or Rob on GPX2 silence-induced resensitization to gefitinib in EGFR-TKI resistant cells. E The effect of NAC or Rob on GPX2 silence-induced resensitization to osimertinib in EGFR-TKI resistant cells. ***P < 0.001, ns no significance.

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