Fig. 2: Mitochondrial fusion (upper row) begins with GTP-activated unfolding of Mfn1/2 monomers on adjacent mitochondria. | Cell Death & Disease

Fig. 2: Mitochondrial fusion (upper row) begins with GTP-activated unfolding of Mfn1/2 monomers on adjacent mitochondria.

From: The role of cardiolipin in mitochondrial dynamics and quality control in neuronal ischemia/reperfusion injury

Fig. 2

Dimerization of mitofusin 1 and 2 (Mfn1/2) brings two mitochondria closer together to begin outer membrane fusion. Inner mitochondrial membrane fusion is driven by optic atrophy 1 (Opa1), which creates protrusions on the inner membrane and begin matrix fusing. Mitochondrial fission (lower row) is actuated by post-translational modification of dynamin-related protein 1 (Drp1) and accumulation of Drp1 receptors on the outer mitochondrial membrane. Drp1 forms an oligomeric ring around the site of fission. ER tubules come in close association with the fission site to complete division.

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