Fig. 4: Mitochondrial fusion of the outer membrane is driven by mitofusin 1 and 2 (MfN 1/2), while the inner membrane requires a healthy balance of optic atrophy 1 (Opa1) isoforms. | Cell Death & Disease

Fig. 4: Mitochondrial fusion of the outer membrane is driven by mitofusin 1 and 2 (MfN 1/2), while the inner membrane requires a healthy balance of optic atrophy 1 (Opa1) isoforms.

From: The role of cardiolipin in mitochondrial dynamics and quality control in neuronal ischemia/reperfusion injury

Fig. 4

Cleaved by Oma1, Opa1 produces short and long isoforms, both of which support fusion. Membrane bound long - Opa1 interacts with cardiolipin on the opposing membrane in a GTPase dependent manner and promotes lipid fusion of the inner membrane.

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