Fig. 1: MC-LR exposure induces inhibition of hepatocyte growth and increases RNA m6A methylation. | Cell Death & Disease

Fig. 1: MC-LR exposure induces inhibition of hepatocyte growth and increases RNA m6A methylation.

From: The dual mechanism of m6A demethylase ALKBH5 in regulating energy metabolism during exposure to MC-LR

Fig. 1

A Pathological observation of liver tissue from MC-LR exposed mice (HE staining). B Effects of MC-LR exposure on proliferation of THLE-3 cells. C Effects of MC-LR exposure on colony forming ability in THLE-3 cells. The m6A methylation level of the liver tissues of mice with exposure to MC-LR was detected by m6A dot blot assay (D) and corresponding quantification (E). The m6A methylation level of total RNA in THLE-3 after 48 h of different doses of MC-LR was detected by m6A dot blot assay (F) and corresponding quantification(G). Data are means ± SD from three independent experiments. *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001; ****P ≤ 0.0001.

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