Fig. 3: Mac-ADSCs influence wild-type cells through paracrine signaling. | Cell Death & Disease

Fig. 3: Mac-ADSCs influence wild-type cells through paracrine signaling.

From: Activating PIK3CA mutations in adipose-derived stem cells drive mutant-like phenotypes of wild-type cells in macrodactyly

Fig. 3

A Venn diagram showing overlap between the differentially expressed genes (DEGs) and the genes encoding secretory proteins in Mac-ADSCs versus Pol-ADSCs. B Heat map of DEGs encoding secretory proteins, with color-coded expression levels. C GO/KEGG pathway analysis of DEGs that encode secretory proteins. D Human cytokine antibody arrays detecting cytokines in the supernatant of Pol-ADSCs (left) and Mac-ADSCs (right). Boxes highlight cytokines with significant differential expression. E Heat map showing the intensities of the dots representing the differentially expressed cytokines (data presented as grayscale values in each group).

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