Table 2 Univariate and multivariate Cox regression analyses of different parameters on overall survival.

From: N6-methyladenosine-mediated upregulation of MANF promotes ER stress resistance in renal cell carcinoma

Parameter

Univariate Analysis

Multivariate Analysis

HR (95%CI)

P Value

HR (95%CI)

P Value

Age

1.039 (1.014-1.064)

0.002

1.028 (1.002–1.054)

0.036

Gender (Female vs. male)

0.946 (0.503-1.778)

0.863

—

—

T stage (T2-T3 vs. T1)

2.115 (1.353-3.307)

0.001

0.819 (0.216–3.110)

0.770

Clinical (TNM) stage (II–III vs. I)

2.179 (1.383-3.431)

<0.001

1.104 (0.285–4.275)

0.886

ISUP (3 + 4 vs. 1 + 2)

1.822 (1.186-2.801)

0.006

1.535 (0.965–2.441)

0.070

Surgery type (Lapar. vs. open)

0.463 (0.261-0.823)

0.009

0.584 (0.316–1.078)

0.085

ALKBH5 expression (High vs. low)

3.516 (2.033-6.082)

<0.001

2.796 (1.481–5.277)

0.002

  1. HR hazard ratio, CI confidence interval.
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