Fig. 2: PANC754 significantly suppressed cell growth and metastasis in CDX model. | Cell Death & Disease

Fig. 2: PANC754 significantly suppressed cell growth and metastasis in CDX model.

From: M6A-METTL3-dependent nuclear PANC754/PSPC1/H3K4me1 repression complex regulate immune evasive LGALS7 signal to enhance immunotherapy against colorectal cancer

Fig. 2

A The pipeline of CRC HCT116 cell line-derived xenograft (CDX; Created by Figdraw). B The presentation of the CDX tumor sizes in three different treatment groups (n = 5, respectively). WT, lentivirus uninfected SW480; Empty, empty lentivirus-infected; PANC754, overexpression PANC754 lentivirus-infected. C The CDX tumor volumes in three treated CDX groups. Empty vector, empty lentivirus vector infected; OE-PANC754, overexpression PANC754 lentivirus vector infected. **P < 0.01. D The representative image of H&E staining in three treatment CDX groups. E The representative image of IHC staining of the proliferation marker Ki67 in three different treatment groups. F–H The protein levels of the metastasis biomarkers MMP9 and E-cadherin in CDX were detected by WB and their statistical histograms. ***P < 0.001.

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