Fig. 3: Transcriptomic changes under bleomycin exposure.
From: Endothelial sensitivity to pro-fibrotic signals links systemic exposure to pulmonary fibrosis
A Functional analysis of up- and downregulated genes under bleomycin exposure. Overrepresentation test with dysregulated genes (absolute LFC ≥1, adjusted p value ≤0.01) against the gene sets of KEGG pathways. The dot size indicates the gene ratio, i.e., the ratio of identified genes to pathway genes. The colour code indicates the Benjamini–Hochberg-adjusted p value of the Fisher’s exact test. The top five enriched pathways are plotted, and already existing pathways are filled even if they are not among the top five pathways. B Expression of apoptosis marker genes for the different experimental conditions of bleomycin exposure. Plotted are the size-factor normalised RNA-Seq counts.
