Fig. 3: On Day 5, bulk RNA sequencing revealed EPO-enriched genes for biological pathways in nerves following SNCI. | Cell Death & Disease

Fig. 3: On Day 5, bulk RNA sequencing revealed EPO-enriched genes for biological pathways in nerves following SNCI.

From: Erythropoietin decreases apoptosis and promotes Schwann cell repair and phagocytosis following nerve crush injury in mice

Fig. 3

A Principal component analysis (PCA) plot shows RNA-sequence transcriptomes (saline-blue; EPO-red). B Heat map depicts the top upregulated (red) and downregulated (blue) differentially expressed genes (DEGs) (FDR ≤ 0.05). C Up and down-regulated DEGs were illustrated in volcano plots to show log 2 (fold change) on the x-axis and significant -log10 (FDR step up) on the y-axis. D Enriched pathways from the DEGs are represented on the y-axis with their associated gene numbers, while the x-axis displays the enrichment score for each pathway. E The Venn diagram illustrates the number of significantly expressed genes (p ≤ 0.05) within pathways identified through a gene set enrichment assay. Saline vs. EPO treatment, n = 4/group.

Back to article page