Fig. 8: EPO increased cell proliferation in nerve tissues following SNCI. | Cell Death & Disease

Fig. 8: EPO increased cell proliferation in nerve tissues following SNCI.

From: Erythropoietin decreases apoptosis and promotes Schwann cell repair and phagocytosis following nerve crush injury in mice

Fig. 8

A, B Representative IF images and quantitative cell proliferation results (anti-Ki67 staining) in saline and EPO-treated nerve tissues on post-SNCI days 3, 5, and 7. n = 5/group. C, D Representative IF images and quantitative results of repair SCs (phalloidin staining) % proliferation (Ki67 positive cells/total cells) following 24 h EPO (10 IU/mL) treatment under LPS (500 ng/mL) stress conditions. n = 3/group. Data are represented as mean ± SEM. The statistical significance is indicated by asterisks (*P < 0.05 and ***P < 0.0002 vs. saline group) and compared using two-tailed, unpaired t-tests or ordinary one-way ANOVA. E A schematic illustration of the role of EPO in rSCs, M2 MΦ myelin phagocytosis, and nerve regeneration following SNCI.

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