Fig. 4: Genetic reduction of Nedd4-2 in db/db mice leads to increased substrate expression. | Cell Death & Disease

Fig. 4: Genetic reduction of Nedd4-2 in db/db mice leads to increased substrate expression.

From: Nedd4-2 ablation in kidney improves glycaemic control in diabetic mice

Fig. 4

A Immunofluorescence of 12-week-old male kidneys. B Male whole kidney lysates assessed for NEDD4-2 and quantitated relative to β-actin in (C), n = 3. D Kidney lysates assessed for ENaC and NCC, band indicated by arrow quantitated relative to β-actin in (E), n = 3. F Immunofluorescence for βENaC or NCC in kidneys. Data presented as mean ± SD and analysed by one-way ANOVA. *P < 0.05, **P < 0.01, ****P < 0.001.

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