Fig. 5: Kidney pathology and function in N42K;db/db mice.
From: Nedd4-2 ablation in kidney improves glycaemic control in diabetic mice
A Body weights of males (black dots) or females (grey dots), average of left and right kidney weights, or kidney/body weight ratios, n = 4-7. B Hematoxylin and Eosin staining of male kidneys at low or high magnification. C Kidneys were scored blind (range 0–4) for indicators of damage, n = 4 males. D 24 h urine samples were measured for albumin, or normalised to creatinine (uACR), and GFR calculated, n = 4–7. Data presented as mean ± SD and analysed by One-way ANOVA. **P < 0.01, ****P < 0.001. Significance in (C) was compared to WT.
