Fig. 3: Simvastatin induces significant transcriptomic changes in SHH- and G3/G4-MB cells. | Cell Death & Disease

Fig. 3: Simvastatin induces significant transcriptomic changes in SHH- and G3/G4-MB cells.

From: Simvastatin suppresses spinal cord metastasis of medulloblastoma at clinically significant doses

Fig. 3

A–D DAOY, D425 and ICb-1299 cells were treated with simvastatin for 72 h before the cells were harvested for RNA-seq library preparation. A Venn diagrams of DEGs of shared or not by the ImmuneScore analyses. B Volcano plots of significant DEGs (FDR-adjusted p < 0.05, |log2 FC| > 0) between high and low expressed genes. C KEGG and D GO enrichment analyses (p < 0.05 and q < 0.05). E Viability assay of DAOY, UW228-2, D425, D458 and ICb-1299 cells after treatment with 2 µM simvastatin for 72 h. Viability evaluated using CellTiter Glo luminescent assay (Promega).

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