Fig. 4: Simvastatin reduced SHH-MB and G3/G4-MB cell migration.
From: Simvastatin suppresses spinal cord metastasis of medulloblastoma at clinically significant doses
A Representative microscopic images of DAOY, UW228-2, ICb-1299 and D458 cells that migrated through the transwell. MB cells were treated with 2 and 5 µM simvastatin. B Quantification of transwell-migrated cells. Data are shown as relative migration ability from three independent experiments. C Scratch assays in adherent SHH cells (DAOY and UW228-2) treated with simvastatin (2 µM and 5 µM). Wound size calculations taken at 0 h and 21 h. D Quantification of migrated DAOY and UW228-2 cells carried out using ImageJ software. One-way ANOVA statistical analysis done using GraphPad Prism software.
