Fig. 9: Effects of METTL3 knockout on the CXCL1/NF-κB signaling axis in HPI gastric inflammation mice. | Cell Death & Disease

Fig. 9: Effects of METTL3 knockout on the CXCL1/NF-κB signaling axis in HPI gastric inflammation mice.

From: Unraveling the Role of METTL3 in Helicobacter pylori-induced gastritis via m6A-CXCL1/NF-κB modulation

Fig. 9

A Western blot analysis of the protein levels of METTL3, CXCL1, p-IκBα, IκBα, p-p65, and p65 in gastric mucosa of mice. B METTL3, CXCL1 and ratios of p-IκBα/IκBα, p-p65/p65 protein levels. C Immunohistochemical staining to detect the expression of CXCL1 in gastric mucosa of mice, scale bar: 50 μm. D Immunofluorescence staining to assess the expression levels of p65 in gastric mucosa of mice, with the right images showing enlarged views of the left images, scale bar: 50 /25 μm. E Immunofluorescence staining to assess the expression levels of p-p65 in gastric mucosa of mice, with the right images showing enlarged views of the left images, scale bar: 50 /25 μm. Each group consisted of 6 mice, values are presented as mean ± standard deviation, * indicates P < 0.05, ** indicates P < 0.01, *** indicates P < 0.001.

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