Fig. 4: DTHIB suppressed proliferation and enhanced chemosensitivity in DLBCL cells. | Cell Death & Disease

Fig. 4: DTHIB suppressed proliferation and enhanced chemosensitivity in DLBCL cells.

From: Heat shock factor 1 promotes proliferation and chemoresistance in diffuse large B-cell lymphoma by enhancing the cell cycle and DNA repair

Fig. 4

A Viability of SU-DHL-2, SU-DHL-4 and SU-DHL-6 cells under DTHIB treatment. Cells were treated with indicated concentrations of DTHIB for 48 h, and the viability was calculated via a CCK8 assay. Data are presented as means ± SDs of three independent experiments. B CCK8 assays of SU-DHL-2, SU-DHL-4 and SU-DHL-6 cells treated with DTHIB or DMSO at the indicated time points. Representative images (C) and quantification (D) of the cell cycle in SU-DHL-2, SU-DHL-4 and SU-DHL-6 cells treated with DTHIB or DMSO were analysed by flow cytometry analysis. Combination index (CI) of SU-DHL-2, SU-DHL-4 and SU-DHL-6 cells treated with a combination of DTHIB and vincristine (E) and a combination of DTHIB and doxorubicin (F). The CI was calculated via CalcuSyn software. A CI less than 1.0 indicates synergy between two drugs. Images (G) and quantification (H) of cell apoptosis in DLBCL cells treated with single agent or combination of DTHIB, vincristine and doxorubicin for 48 h. *p < 0.05, **p < 0.01.

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