Fig. 5: DTHIB inhibited tumorigenesis and enhanced the efficacy of vincristine and doxorubicin in DLBCL in vivo. | Cell Death & Disease

Fig. 5: DTHIB inhibited tumorigenesis and enhanced the efficacy of vincristine and doxorubicin in DLBCL in vivo.

From: Heat shock factor 1 promotes proliferation and chemoresistance in diffuse large B-cell lymphoma by enhancing the cell cycle and DNA repair

Fig. 5

A Schematic illustration of the establishment of the in vivo chemotherapy assay model. B Images of surgically dissected tumors in indicated groups. C The volume of tumors in indicated groups was measured every 3 days. D The weights of the tumors in indicated groups were measured after the tumors were surgically dissected. The results are presented as the means ± SDs (n = 6). E, F Representative images (F) and H-scores of Ki67 (E) in tumors from indicated groups. Representative images of apoptosis in tumors (G) and the percentage of TUNEL-positive cells (H) in indicated groups. The scale bars in the IHC and TUNEL images represent 50 μm. *p < 0.05, **p < 0.01.

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