Fig. 4: FIBCD1 enhances the malignancy of BC cells in a glucose level-dependent manner. BC cells were incubated in hyperglycemic (25 mM glucose) or euglycemic (5 mM glucose) culture conditions, respectively. | Cell Death & Disease

Fig. 4: FIBCD1 enhances the malignancy of BC cells in a glucose level-dependent manner. BC cells were incubated in hyperglycemic (25 mM glucose) or euglycemic (5 mM glucose) culture conditions, respectively.

From: Diabetes is causally associated with increased breast cancer mortality by inducing FIBCD1 to activate MCM5-mediated cell cycle arrest via modulating H3K27ac

Fig. 4

A High glucose enhances the promoting effect of FIBCD1 on cell proliferation in MCF7 cells. B Cell counting assay indicates that the effects of FIBCD1 on cell proliferation are stronger under high glucose conditions. C Proliferation of MCF7 cells by FIBCD1 was determined by cell counting assay. D Proliferation of MDA-MB-231 cells by FIBCD1 was measured by cell counting assay. E Hyperglycemia enhances the effects of FIBCD1 on cell migration ability of MCF7 cells. F Hyperglycemia increases the impacts of FIBCD1 on cell migration ability in MDA-MB-231 cells. G High glucose augments the promotive effects of FIBCD1 on cell invasion capacity of MCF7 cells. H High glucose promotes the influence of FIBCD1 on cell invasion ability of MDA-MB-231 cells. I Knockdown of FIBCD1 suppresses the proliferation rate of MAD-MB-231 cells. J Silencing of FIBCD1 inhibits proliferation capacity of MDA-MB-231 cells. K Knockdown of FIBCD1 depresses migration ability of MCF7 cells. L Silencing of FIBCD1 suppresses invasion capacity of MDA-MB-231 cells. Data are presented as mean ± SD, Student’s t test. *P < 0.05; **P < 0.01; ***P < 0.001.

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