Fig. 5: Knockdown of FIBCD1 inhibits BC tumor growth in diabetic mice. | Cell Death & Disease

Fig. 5: Knockdown of FIBCD1 inhibits BC tumor growth in diabetic mice.

From: Diabetes is causally associated with increased breast cancer mortality by inducing FIBCD1 to activate MCM5-mediated cell cycle arrest via modulating H3K27ac

Fig. 5

A Schematic overview of the in vivo experiment. B Blood glucose levels in sh-FIBCD1 treatment mice and control animals. C Comparison of body weight changes of mice during the experiment. D. The average xenograft tumor weight in si-FIBCD1-treated diabetic mice is significantly lower than that of control animals. E Tumor growth curves indicate that sh-FIBCD1 treatment significantly inhibits tumor growth in diabetic mice. F Representative images of xenograft tumors in diabetic mice with or without si-FIBCD1 treatment. G Representative images of IHC staining, indicating that sh-FIBCD1 suppresses the expression levels of Ki67 protein expression in xenograft tumor tissues. H sh-FIBCD1 inhibits MCM5 protein expression in xenograft tumor tissues. Data are presented as mean ± SD, Student’s t test. *P < 0.05; **P < 0.01; ***P < 0.001.

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