Fig. 4: circPSD3 promotes cell proliferation by regulating the TCA cycle in thyroid carcinoma. | Cell Death & Disease

Fig. 4: circPSD3 promotes cell proliferation by regulating the TCA cycle in thyroid carcinoma.

From: CircPSD3 aggravates tumor progression by maintaining TCA cycle and mitochondrial function via regulating SUCLG2 in thyroid carcinoma

Fig. 4

A, B Flow cytometry and statistical results demonstrate the decreased MMP in the sh-circPSD3 group, which was rescued by regaining α-ketoglutarate and succinate in TPC-1. C, D Flow cytometry and statistical results demonstrate the increased apoptotic cell rate in the sh-circPSD3 group, which was rescued by regaining α-ketoglutarate and succinate in TPC-1. E, F Representative EdU fluorescence images and statistical results demonstrate the inhibitory effect on proliferation of circPSD3-knockdown, which was rescued by regaining α-ketoglutarate and succinate in TPC-1. G, H The suppressed OCR and decreased ATP production in the sh-circPSD3 group, which was rescued by regaining α-ketoglutarate and succinate in TPC-1. The experiments were repeated 3 times independently. Data are presented as the mean ± S.D. α-kg α-ketoglutarate, suc succinate, NC negative control group, sh sh-circPSD3 group. *P < 0.05; **P < 0.01; ***P < 0.001.

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