Table 3 Metabolic enzymes involved in the anoikis resistance in GC.

NOX4

Upregulation of EGFR

Increasing ROS production

in vitro (GES-1, AGS and MKN45 cells)

in vivo (mice)

human tissue samples

in silico (LinkedOmics)

[114]

ME1

Increasing ROS production by

ME1-ETV4 axis,

in vitro (GES1, AGS, SGC7901, SNU216, BGC823, HGC27, MGC803, NUGC4, MKN45 and MKN74 cells)

in silico (CCLE and TCGA)

human tissue samples (N = 207)

in vivo (BALB/c nude mice)

[115]

GPX4

Inhibition of anoikis-induced

ferroptosis

in vitro (AGS, MKN45, HGC27 cells)

tumor tissues from 54 GC patients with and without lymphatic metastasis

[116]

DGT2

Activation of C/EBPα

GC tissue specimens (N = 318)

and freshly collected primary tumor tissues and matched metastasis tissues (N = 8)

in vivo (BALB/c nude mice)

[117]

FASN

Activation of ERK1/2 pathways

Activation of Bcl-xL

in vitro (GES-1, GC, MNK-45 and AGS cells)

[120]