Fig. 4: Therapeutic JQ-1 administration improves cardiac remodeling in MI mice.

A Schematic representation of the protocol for the treatment of MI mice with JQ-1. JQ-1 (50 mg/kg) or equivalent vehicle was injected intraperitoneally 1 day after MI. B Heart rate of JQ-1-treated mice after 28 days of MI (n = 6). C Representative M-mode echocardiography images in mice 28 days post MI treated with JQ-1. D Effect of JQ-1 treatment on LVEF and LVFS at indicated days after MI (n = 6). E Heart weight to tibial length ratios in mice 28 days post MI treated with JQ-1 (n = 6). F Representative H&E and Masson’s trichrome stained of heart sections from mice 28 days post MI treated with JQ-1. Scale bars, 1 mm. Quantification of the fibrosis area (G) and infarct area (H) of the myocardium from mice 28 days post MI treated with JQ-1 (n = 6). I Effect of JQ-1 treatment on Nppa, Nppb, and Myh7 mRNA levels in the cardiac tissue from mice 3 days post-MI (n = 6). The cardiac GSH/GSSG levels (J) and MDA levels (K) from mice 3 days post-MI (n = 6). L Analysis of Ptgs2 and Hmox1 mRNA levels of the myocardium in mice 3 day after MI (n = 6). The data are presented as mean ± SEM. The statistical significance of the data was evaluated using a Student’s two-tailed t test (H), and two-way ANOVA followed by Tukey’s test for multiple comparisons (B, D, E, G and I–L). *P < 0.05; **P < 0.01.