Fig. 5: USP43 binds to and attenuates the proteasome-mediated degradation of FASN. | Cell Death & Disease

Fig. 5: USP43 binds to and attenuates the proteasome-mediated degradation of FASN.

From: YY1-induced USP43 drives ferroptosis suppression by FASN stabilization and subsequent activation of SLC7A11 in ovarian cancer

Fig. 5

A, B Exogenous immunoprecipitation confirming the interaction between FASN and USP43. C Endogenous immunoprecipitation validating the interaction between FASN and USP43. D Immunofluorescence showing colocalization of USP43 and FASN. E Regulation of FASN protein expression by USP43 in the presence of MG132 (20 μM). F Regulation of FASN protein expression by USP43 in the presence of CHX (100 μg/ml). G Changes in FASN expression levels based on USP43 levels. H Regulation of FASN expression by the C110S mutant of USP43. I Regulation of FASN ubiquitination levels by USP43.

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