Fig. 6: USP43 reduces the ubiquitination level of FASN. | Cell Death & Disease

Fig. 6: USP43 reduces the ubiquitination level of FASN.

From: YY1-induced USP43 drives ferroptosis suppression by FASN stabilization and subsequent activation of SLC7A11 in ovarian cancer

Fig. 6

A Overexpression of USP43 reduces the ubiquitination level of FASN in ovarian cancer cells. B C110S mutation abrogates the effect of USP43 on FASN ubiquitination. C The schematic diagram illustrating the truncation of full-length USP43. D Truncation experiments identifying the specific binding regions of USP43 with FASN. E Ubiquitination assays revealed the effect of truncated USP43 on the ubiquitination of FASN.

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