Fig. 7: USP43 modifies HIF1α and SLC7A11 by regulating FASN stability. | Cell Death & Disease

Fig. 7: USP43 modifies HIF1α and SLC7A11 by regulating FASN stability.

From: YY1-induced USP43 drives ferroptosis suppression by FASN stabilization and subsequent activation of SLC7A11 in ovarian cancer

Fig. 7

A, B Western blotting experiments were conducted to estimate the expression levels of FASN and HIF1α after USP43 knockdown and overexpression. C We used western blotting to analyze the expression of HIF1α in the cytoplasm and nucleus after USP43 overexpression. D Overexpression of HIF1α increases SLC7A11 mRNA levels (n = 3). E Overexpression of HIF1α increases SLC7A11 protein levels. F, G The mRNA levels of SLC7A11 assessed using RT-qPCR after FASN was overexpressed in USP43-knockdown cells (n = 3). H, I The protein levels of HIF1α and SLC7A11 assessed using Western blot after FASN was overexpressed in USP43-knockdown cells. Data are presented as mean ± SD.

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