Fig. 8: PRMT1 and methylated UBE2m are upregulated in the kidneys of patients with stones and positively correlated with renal injury markers.

A Representative immunohistochemical staining images (400X) and quantitative analysis of the expression of M-UBE2m in the nonfunctioning kidney of patients with stones or the control. Scale bars = 50 μm. B Pearson correlation analysis of the expression of PRMT1 and M-UBE2m. C Representative immunohistochemical staining images (400X) and quantitative analysis of the expression of KIM-1 in the nonfunctioning kidney of patients with stones or the control. Scale bars = 50 μm. D–G Pearson correlation analysis of the expression of PRMT1 and eGFR (D), PRMT1 and KIM-1 (E), M-UBE2m and eGFR (F), M-UBE2m and KIM-1 (G). Significance was assessed using t-tests. Data are presented as mean ± SD.