Fig. 2: ZC3H13 knockdown inhibited the proliferation, invasion and migration of GC cells in vitro. | Cell Death & Disease

Fig. 2: ZC3H13 knockdown inhibited the proliferation, invasion and migration of GC cells in vitro.

From: ZC3H13 mediates N6-methyladenosine modification of SNTB1 to promote epithelial-mesenchymal transition in gastric cancer

Fig. 2

A, B Endogenous expression of ZC3H13 in GC cell lines. ZC3H13 mRNA and protein expression decreased in AGS (C) and HGC-27 (D) cells after transfection with either shZC3H13-1 or shZC3H13-2. E ZC3H13 knockdown inhibited the proliferation capacity and colony formation of AGS and HGC-27 cells. F Down-expression of ZC3H13 inhibited the proliferative viability of AGS and HGC-27 cells. ZC3H13 knockdown inhibited the migration (G) and invasion (H) ability of AGS cells, as well as HGC-27 (I, J) cells. Wound healing assays revealed that ZC3H13 knockdown weakened the migration ability of AGS (K) and HGC-27 (L) cells. *P < 0.05, **P < 0.01, and ***P < 0.001 represent varying degrees of significance between the indicated groups.

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