Fig. 5: P2X7 and A2A combined antagonism decreases P2X7 and A2A expression in the metastatic niche. | Cell Death & Disease

Fig. 5: P2X7 and A2A combined antagonism decreases P2X7 and A2A expression in the metastatic niche.

From: P2X7 a new therapeutic target to block vesicle-dependent metastasis in colon carcinoma: Role of the A2A/CD39/CD73 axis

Fig. 5

A–J BALB/c mice were injected intravenously with CT26 Luc2 cells and treated intraperitoneally with placebo, AZ10606120 (2 mg/Kg), SCH58261 (1 mg/Kg), or a combination of both drugs. Percentage of lung cells positive for P2X7 A and A2A F staining (n = 4). Representative immunohistochemistry images of mice treated with placebo B, G, P2X7 antagonist AZ10606120 (C, H), A2A antagonist SCH58261 D,I, or both drugs E,J. *p < 0.05.

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