Fig. 7: P2X7, CD39, CD73, and A2A expression significantly increased in the advanced stages of CRC. | Cell Death & Disease

Fig. 7: P2X7, CD39, CD73, and A2A expression significantly increased in the advanced stages of CRC.

From: P2X7 a new therapeutic target to block vesicle-dependent metastasis in colon carcinoma: Role of the A2A/CD39/CD73 axis

Fig. 7

The mRNA expression of P2X7A A, B, P2X7B C, D, CD39 E, F, CD73 G, H, and A2A I, J was evaluated in the cDNAs of 158 patients with CRC subdivided into stage I (n = 24), stage II (n = 50), stage III (n = 52), and stage IV (n = 32) which comprised 11 samples derived from metastases in organs other than the colon. K Spearman’s correlation coefficient among P2X7A, P2X7B, CD39, CD73, and A2A was evaluated in CRC metastatic patients. L Spearman’s correlation coefficient was evaluated between P2X7 and A2A expression in colon adenocarcinoma samples obtained from the Cancer Genome Atlas database. *p < 0.05, **p < 0.01, ***p < 0.001. ****p < 0.0001.

Back to article page