Fig. 3: Prdx1 knockout attenuated intestinal inflammation.

Prdx1^–/– mice and their littermates received 4% DSS for 7 consecutive days. A Body weight of the mice was monitored daily and the data was plotted as a percentage of the initial body weight on Day 0 (n = 12 mice per group). B The disease activity of Prdx1^–/– mice and their littermates was monitored and scored daily (n = 12 mice per group). C Survival of mice monitored over a period of 14 days (n = 12 mice per group). D Typical images of H&E staining and histopathological scores of colon sections from the indicated mouse groups (n = 5 mice per group). Scale bar, 50 μm. E Colonic endoscopic images and murine endoscopic index of colitis severity (MEICS) scores of mice from the indicated groups (n = 4 mice per group). F–H The mRNA expression levels of IL-1β, IL-6, and TNF-α in the colons of indicated mouse groups were measured by RT-qPCR (n = 5 mice per group). Data are expressed as mean ± SD; ^*P < 0.05, ^**P < 0.01 by non-paired Student’s t test (A–C) or one-way ANOVA (D–H). Results presented were repeated at least three independent experiments for each experimental condition.