Table 1 Concentrations of G4Ls inhibiting osteosarcoma cell growth.

From: Cellular adaptations impact the biological activity of naphthalene diimide G-quadruplex ligands in ALT-positive osteosarcoma cells

 

IC50 (nM)

IC80 (nM)

NMe2

QN-302

NMe2

QN-302

U-2 OS

230 ± 20

16 ± 1

610 ± 30

64 ± 9

Saos-2

410 ± 30

43 ± 2

1600 ± 80

282 ± 21

  1. Concentrations of G4Ls inhibiting 50% (IC50) and 80% (IC80) of cell growth obtained after a 2-day exposure to the indicated compounds.
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