Fig. 4: LINC00183 promotes aerobic glycolysis in CRC. | Cell Death & Disease

Fig. 4: LINC00183 promotes aerobic glycolysis in CRC.

From: Platelet-derived exosomal LINC00183 facilitate colorectal cancer malignant progression driven by histone lactylation through stabilizing ENO1

Fig. 4

A Heatmap of all differentially expressed genes in HT29 cells transfected with LINC00183 overexpression or control plasmids. B Volcano plot of transcriptome sequencing data. C GSEA results showing DEG enrichment in the glycolysis pathway. D Heatmap of all differentially expressed metabolites in HT29 cells transfected with LINC00183 overexpression or control plasmids. E Volcano plot of central carbon metabolism from metabolomics sequencing data. F GSEA of central carbon metabolism metabolites. G–L Analysis of glucose uptake, ATP production, and lactate generation in cultured HT29 CRC cells. M–P ECAR measurements in cultured HT29 CRC cells. Q PET-CT analysis of glucose uptake in mice bearing subcutaneous CRC xenografts.

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