Fig. 6: Endo-lysosomes disturbance is the upstream of increased vulnerability.
From: A unique subpopulation of wild-type neurons recapitulating familial Alzheimer’s disease phenotypes
A Neurons were treated with 100 μM CQ, 100 nM Baf A1, or vehicle control for 5 h, followed by time-lapse imaging to measure the time until becoming PI (+) on a cell-by-cell basis in response to DTDP treatment. B Neurons treated with CQ or Baf A1 exhibited significantly shorter time until becoming PI positive compared to vehicle control. Scale bar 50 μm. N = 60–92 neurons. One-way ANOVA, **<0.01, ****<0.0001.
