Fig. 8: P4HA2 and miR-30e expression are associated with BC progression and patient outcomes. | Cell Death & Disease

Fig. 8: P4HA2 and miR-30e expression are associated with BC progression and patient outcomes.

From: The ETS transcription factor GABPA inhibits bladder cancer aggressiveness by repressing extracellular matrix deposition and mechanotransduction signaling

Fig. 8

A–D TCGA BLCA cohort analyses. A BC tumor at advanced stages and higher grades expresses significantly increased P4HA2 mRNA. B miR-30e expression was significantly downregulated in BC tumors at advanced stages and high grades. C K-M plots showed that higher P4HA2 mRNA expression was associated with significantly shorter overall and progression-free survival (OS and PFS) in BLCA patients. D Higher miR-30e expression is associated with longer OS and PFS. E Higher protein levels of P4HA2 predict significantly shorter OS in our cohort of BC patients. Left: representative IHC staining of P4HA2, and right: K-M plot showing significant association between higher P4HA2 expression and shorter OS.

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