Fig. 6: RNA-seq analysis in MCM7 and SHCBP1 knockdown cells upon IL-1β stimulation.
From: MCM7 promotes liver fibrosis by transcriptionally regulating IL11 via the SHCBP1-RACGAP1-STAT3 axis
A, B Volcano plots of differentially expressed genes in MCM7-knockdown (A) or SHCBP1-knockdown (B) cells treated with IL-1β. Upregulated genes are highlighted in red, and downregulated genes in blue. C, D Venn diagrams illustrating the overlap of upregulated (C) and downregulated (D) differentially expressed genes between MCM7-knockdown and SHCBP1-knockdown cells upon IL-1β treatment. E, F Pathway analysis of the upregulated overlapping genes (E) and downregulated overlapping genes (F). G Table listing significantly differentially expressed genes from the cytokine-cytokine receptor interaction network. H Heatmap depicting the downregulated expression of genes in both MCM7-knockdown and SHCBP1-knockdown cells upon IL-1β treatment. I Genome browser tracks of RNA-Seq signals at the IL11 gene in PLKO.1, MCM7-knockdown, and SHCBP1-knockdown cells after IL-1β treatment.
