Fig. 3: The p-STING/p-IRF3 axis plays a crucial role in NAD+-mediated activation of T cell function and anti-tumor immunity. | Cell Death & Disease

Fig. 3: The p-STING/p-IRF3 axis plays a crucial role in NAD+-mediated activation of T cell function and anti-tumor immunity.

From: NAD+ Metabolism-Mediated SURF4-STING Axis Enhances T-Cell Anti-Tumor Effects in the Ovarian Cancer Microenvironment

Fig. 3

A, B NAMPT promotes the activation of the p-STING/p-IRF3 axis in T cells. C-D. Reduced NAD+ levels inhibit the activation of the p-STING axis, while NAM promotes the activation of the p-STING/p-IRF3 axis in T cells. E, F Inhibition of STING significantly attenuates the NAM-promoted activation of downstream p-IRF3. G, H Inhibition of STING in T cells markedly reduces the expression of NAM-activated anti-tumor effector proteins. I Inhibition of STING in T cells significantly downregulates the expression of NAM-activated anti-tumor factors. J–L Inhibition of STING in T cells significantly weakens the NAM-enhanced cytotoxic ability of T cells. J After STING inhibition in T cells, the NAM-promoted inhibitory effect of T cells on the proliferation of HEY is significantly reduced. K, L After STING inhibition in T cells, the number of apoptotic SKOV3 decreases. M STING inhibition diminishes the NAM-promoted enhancement of T cell chemotaxis. N, O STING inhibition weakens the NAM-promoted proliferation of T cells, reducing the number of cells in the S/G2M phase.

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