Fig. 3: FGF15/FGFR4 signaling inhibits M1 polarization of septic macrophages and their inflammatory responses. | Cell Death & Disease

Fig. 3: FGF15/FGFR4 signaling inhibits M1 polarization of septic macrophages and their inflammatory responses.

From: FGF15/FGFR4 signaling suppresses M1 macrophage polarization and multi-organ inflammation in septic mice by inhibiting H3K18 lactylation-driven Irf7 expression through NF2-Hippo activation

Fig. 3

A Detection of the pro-inflammatory mediators TNF-α, IL-1β, IL-6, COX-2, and iNOS and anti-inflammatory mediators IL-10 and TGF-β in peripheral blood of Sham, CLP and rFGF15-treated CLP (CLP + rFGF15) mice by ELISA. n = 9, *p < 0.05. B Detection of CD86 (a marker of M1-like macrophages) and CD206 (a marker of M2-like macrophages) in mouse BMDMs and RAW264.7 macrophages following treatment with vehicle (Control), LPS, LPS + rFGF15, LPS + rFGF15 + si-NC, or LPS + rFGF15 + si-FGFR4 by flow cytometry. C Detection of the pro-inflammatory mediators TNF-α, IL-1β, IL-6, COX-2, and iNOS and anti-inflammatory mediators IL-10 and TGF-β in mouse BMDMs and RAW264.7 macrophages following treatment with vehicle (Control), LPS, LPS + rFGF15, LPS + rFGF15 + si-NC, or LPS + rFGF15 + si-FGFR4 by ELISA. n = 6, *p < 0.05.

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