Fig. 5: FGF15/FGFR4 signaling inhibits glycolysis, H3K18 lactylation, M1 polarization, and inflammation of septic macrophages through the NF2-Hippo pathway. | Cell Death & Disease

Fig. 5: FGF15/FGFR4 signaling inhibits glycolysis, H3K18 lactylation, M1 polarization, and inflammation of septic macrophages through the NF2-Hippo pathway.

From: FGF15/FGFR4 signaling suppresses M1 macrophage polarization and multi-organ inflammation in septic mice by inhibiting H3K18 lactylation-driven Irf7 expression through NF2-Hippo activation

Fig. 5

A–F Assessment of glucose uptake (A), lactate production (B), glycolytic enzyme expression (C), H3K18 lactylation (D), M1/M2 polarization (E), and pro- and anti-inflammatory mediator production (F) in mouse RAW264.7 macrophages overexpressing the wildtype NF2 (NF2-WT) or phospho-null NF2 mutant (NF2-Mut) following treatment with LPS or LPS + rFGF15. n = 6, *p < 0.05.

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