Fig. 1: Illustration to show the generation process of supercharged NK cells.

Human peripheral blood mononuclear-derived NK cells were activated with rh-IL-2 (1000 U/ml) and anti-CD16 mAb (3 µg/ml) for 18–20 h before they were co-cultured with OCs and probiotic bacteria sAJ2 (OCs:NK:sAJ2; 1:2:4). The medium was refreshed every three days with RPMI containing rh-IL-2 (1500 U/ml).