Fig. 2: Activation of mitochondrial machinery is common across all phenotypes on serum depletion. | Cell Death & Disease

Fig. 2: Activation of mitochondrial machinery is common across all phenotypes on serum depletion.

From: Targeting mitochondrial translation and OXPHOS in high-grade serous ovarian carcinoma eliminates stem-like cells

Fig. 2

a Venn diagram representing enriched (shared and unique) pathways following SS; b A heatmap illustrating RAECTOME pathway enrichment, based on enrichment p-values, depicting molecular pathways significantly enriched in SS compared to the corresponding +S condition across the phenotypic spectrum (enriched mitochondrial translation pathways, p < 0.05, are highlighted at the top of the heatmap); c Bar graph indicating enriched GO terms across HGSC phenotypes following SS (number of proteins corresponding to each GO term indicated on the bar); d LFQ intensity scatter plot indicating distribution of SS-enriched mitochondria-related proteins across the phenotype gradient (green-E, red-iE, blue-E/M, yellow-iM and black-M); e Horizontal bar graph representing enrichment of stemness-related pathways under SS across phenotypes *p < 0.05, **p < 0.01, and ***p < 0.001.

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